Analytical Technologies Singapore

Copley’s comprehensive range of world leading products for inhaler testing extends to equipment, software and services for every stage of development for both innovator and generic products. 

The devices used for inhaled and nasal drug delivery are collectively referred to as orally inhaled and nasal drug products (OINDPs). Contact us for more information of the products.

The DDU is the total mass of drug emitted from the inhaler and hence available to the patient.Delivered Dose Uniformity (DDU) is measured by firing the test device into a sampling apparatus which contains a filter. The active drug caught on the filter is then dissolved in solvent and analysed using High Pressure Liquid Chromatography (HPLC).

The Aerodynamic Particle Size Distribution (ASPD), along with Delivered dose, is widely recognised as a Critical Quality Attribute in the in vitro characterisation of OINDPs. The ASPD of an aerosol will determine where the particles in that cloud are going to deposit in the body, amongst other information. 

IVIVC Test Systems for DDU and APSD

Nebuliser

Nebuliser for for DDU and APSD

MDIs/DPIs/ADIs

MDIs/DPIs/ADIs System for DDU & APSD

Nasal Products

Aid in realistic breathing profiles and realistic throat and nasal models

Inhaled Dissolution

Watchglass/PTFE Assembly for use with ACI

Allows size-fractionated particles from an aerosol cloud to be collected for inhaler dissolution testing

NGI Dissolution Cup

A modification of the standard NGI collection cup for inhaler dissolution

Facemask Testing

Facemask Testing

Investigating and defining the effect of a facemask to the product’s DDU and APSD is important for the product development

IVIVCs Spacers

The gap between the facemask and the patient

Morphology

Morphology

Provides a useful indication of where inhaled drug particles are likely to deposit within the respiratory tract

Cold Freon® Effect

Plume Temperature Tester Model PTT 1000

Cold Freon® Effect- consists of a polypropylene sampling tube

Spray Force Tester Model SFT 1000

High precision instrument for measuring the maximum impaction force of MDIs and nasal sprays over the duration of the spray plume.