Analytical Technologies Singapore

Copley’s comprehensive range of world leading products for inhaler testing extends to equipment, software and services for every stage of development for both innovator and generic products. 

The devices used for inhaled and nasal drug delivery are collectively referred to as orally inhaled and nasal drug products (OINDPs). Contact us for more information of the products.

The DDU is the total mass of drug emitted from the inhaler and hence available to the patient.Delivered Dose Uniformity (DDU) is measured by firing the test device into a sampling apparatus which contains a filter. The active drug caught on the filter is then dissolved in solvent and analysed using High Pressure Liquid Chromatography (HPLC).

The Aerodynamic Particle Size Distribution (ASPD), along with Delivered dose, is widely recognised as a Critical Quality Attribute in the in vitro characterisation of OINDPs. The ASPD of an aerosol will determine where the particles in that cloud are going to deposit in the body, amongst other information. 

Broad range of labour-saving devices and systems that automate many routine and tedious testing procedures for both delivered dose uniformity (DDU) testing and aerodynamic particle size distribution (APSD) measurement.

Automated Shake, Fire and Flow Control for MDIs, Nasal Sprays and Aerosols

Vertus® III

Automated Shake, Fire and Flow Control for MDIs, Nasal Sprays and Aerosols

Vertus® III+

Vertus III, but in addition has an integrated 5 decimal place weighing balance

DecaVertus® III

Fully-automated, high throughput 10-way shake and fire to waste system for metered dose inhaler (MDI) testing.

Automation for DDU Testing

DUSA Shaker™ DTS 100i

Automation for Dose Uniformity Sampling appropriate to its type (MDI or DPI) prior to assay

Automation for APSD Testing

Impactor Genie™ IG 200i

Automated Impaction Surface Coating and Sample Recovery for ASPD testing

Gentle Rocker GR 200i

Automated Sample Recovery for APSD testing

Sample Preparation Unit SPU 200i

Automates repetitive drug recovery procedures, reducing the unwanted effects of repetitive strain injury (RSI).

Impactor Coater™ IC 200i

Automated Impaction Surface Coating for APSD of OINDPs

Impactor Cleaning System

Semi-Automation for APSD Testing